Aldehydes: Magnificent acyl equivalents for direct acylation

From the viewpoint of meeting the current green chemistry challenges in chemical synthesis, there is a need to disseminate how the cocktail of acylation and activation can play a pivotal role in affording bioactive acylated products comprising substituted ketone motifs in fewer reaction steps, with higher atom-economy and improved selectivity. In recent years, a significant number of articles employing the title compounds "aldehydes"as magnificent acylation surrogates which are less toxic and widely applicable have been published. This review sheds light on the compounds use for selective acylation of arene, heteroarene and alkyl (sp3, sp2 and sp) C-H bonds by proficient utilization of the C-H activation strategy. Critical insights into selective acylation of diverse moieties for the synthesis of bioactive compounds are presented in this review that will enable academic and industrial researchers to understand the mechanistic aspects involved and fruitfully employ these strategies in designing novel molecules. © The Royal Society of Chemistry.

Authors
Kumar P.1, 2 , Dutta S.2 , Kumar S.2 , Bahadur V.1, 2 , Van Der Eycken E.V. , Vimaleswaran K.S.5 , Parmar V.S.6 , Singh B.K.2
Publisher
Royal Society of Chemistry
Number of issue
40
Language
English
Pages
7987-8033
Status
Published
Volume
18
Year
2020
Organizations
  • 1 Department of Chemistry, SRM University Delhi-NCR, Sonepat Haryana, 131029, India
  • 2 Department of Chemistry, University of Delhi, Delhi, 110007, India
  • 3 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, B-3001, Belgium
  • 4 Peoples' Friendship University of Russia, (RUDN University), Miklukho-Maklaya street 6, Moscow, 117198, Russian Federation
  • 5 Hugh Sinclair Unit of Human Nutrition, School of Chemistry, Food and Pharmacy, University of Reading, United Kingdom
  • 6 Department of Chemistry and Environmental Science, Medgar Evers College, City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, United States
Keywords
Activation analysis; Aldehydes; Chemical activation; Ketones; Synthesis (chemical); Acylated products; Bioactive compounds; C-h activation; Green chemistry; Mechanistic aspects; Novel molecules; Reaction steps; Title compounds; Acylation
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72440/
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