To ward off the outbreak of the coronavirus disease (COVID-19) in 2019, the Jordanian government applied quarantine to the Jordanian population in addition to Syrian refugees. We evaluated the quarantine's psychological effect on people in Jordan after three weeks of quarantine. The prevalence of post-traumatic stress disorder (PTSD) in our sample population was determined using a higher than twenty score on the Impact of Event Scale-Revised (IES-R). The 2380 people who received the survey online demonstrated a high prevalence of PTSD, in which PTSD showed incidence of 82.5% and 66.5 in Syrian refugees and Jordanian populations, respectively. This study also reports the trend towards more increased PTSD prevalence in Syrian refugees compared to the Jordanian population depending on age, education and the household's combined monthly income. Knowledge and awareness of quarantined people's interactions are crucial to optimizing control of infectious diseases and reducing adverse impacts on those quarantined. © 2021 The Authors. International Migration © 2021 IOM