Diagnosis of geneticforms of azoosper

Aim: To identify the main genetic causes of azoospermia. Methods. The study included 92 patients with azoospermia. In all patients we carried out genetic tests - karyotyping, PCRdiagnosis of blood. Results. Genetic disorders were found in 35 (38%) men. Of these, the majority of men were with Kleinfelter syndrome - 21 (60%) and deletions in the AZF regions of the Y chromosome - 11 (31.4%). Conclusions. Patients who have genetic abnormalities should receive comprehensive medical and genetic advice.

Authors
Sturov N.V. 1 , Myandina G.I. 1 , Tarasova T.2 , Saushev I.2 , Pashina N.3 , Korovyakova E.A. 1 , Barkhudarov A.A. 1 , Strachuk A.G. 1 , Karaseva N.V. 1 , Druzhinina N.K. 1 , Pashin S.3
Journal
Archiv Euromedica
Publisher
European Scientific Society
Number of issue
2
Language
English
Pages
111-113
Status
Published
Volume
9
Year
2019
Organizations
  • 1 Peoples Friendship University of Russia
  • 2 Ogarev Mordovia State University
  • 3 The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Keywords
Male infertility, azoospermia, chromosomal abnormalities, Kleinfelter syndrome, AZF microdeletions
Date of creation
02.11.2020
Date of change
02.11.2020
Short link
https://repository.rudn.ru/en/records/article/record/70846/
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ЕРМАКОВ Д.С., КИРИЛЛОВ П.Н.
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