Objective. To analyze the metadata of modern scientific literature on the most significant changes in algorithms of secondary preventive measures in cervical cancer with link to appraisal of the role of human papilloma virus (HPV) in the nature of cervical cancer. Material and methods. The article includes the data of foreign and local Russian articles published in past years and found in Pubmed. Results. Reported usage of immunomodulating and aniviral medication which helps to increase the efficacy of HPV therapy. Conclusion. Combine therapy with targeted elimination of affected area by electro surgery together with immunomodulating administration helps to increase efficacy of secondary preventive measures in treatment of cervical cancer. © Bionika Media Ltd.