In Russia, winter wheat represents important production with a significant proportion in the whole agricultural system. However, response of new winter wheat varieties to intensive management practices with fertilizers and pesticides can pave a way towards improved yield and quality of the produce. This paper aimed to study the reaction of spring wheat varieties to the levels of mineral fertilizers and plant protection products. Three cultivation technologies were investigated identified as Basic (T1), Intensive (T2) and High Intensive (T3) with fertilizers, pesticides and growth regulators at different combinations and concentrations. Three spring wheat varieties were studied Zlata, Liza and Agata. Yield performance and grain quality (calculated through protein and gluten content) were measured simultaneously. The results showed that the wheat varieties performances increased according to the used technology. The highest yield was observed in the high-intensive technology with 9.04 t/ha 9.05 and 9, 07 t/ha in Zlata (V1), Liza (V2) and Agata (V3) varieties, respectively. The yield decreased by 20-40% using the Basic technology in all the studied varieties. The grain quality was affected similarly according to the tested technology. The results showed that the High Intensive technology (T3) was the most effective in terms of proteins and gluten contents with 3 to 4% more than the Basic technology (T1). The current study showed that application of potent treatments and selection of potential varieties could significantly enhance spring wheat yield and grain quality in Moscow region. © 2020 Polityko et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License.