The aimed of the study was to research of health of newborns from mothers with gestational diabetes mellitus. Methods: The study included 210 pregnant women with gestational diabetes mellitus (GDM) and 200 without disorders of carbohydrate metabolism, who gave birth during the period: II quarter of 2017 III quarter of 2018 in the maternity ward of the city clinical hospital No. 29 named after N.E. Bauman in Moscow. This was a prospective case-control study. Results: One of the leading problems of the early neonatal period was morpho-functional immaturity: more than half of the children from mothers with GDM were born with signs of immaturity - 115 (54.8%). In the "on insulin therapy" group, children were 5 times more likely to have cardiomyopathy than those from mothers who were on a diet. With the same frequency in the control group, and for newborns from mothers with GDM, heart defects occurred: 20 (9.5%) and 24 (12.1%), respectively (p> 0.05). The main part of them were small (valvular) heart defects: defects of the interventricular and interatrial septums (18 (8,6%) in GDM group). Conclusion: The level of health in the early neonatal period of newborns from mothers with GDM in modern conditions is determined mainly by morpho-functional impairments. The incidence of newborns from mothers who were on insulin therapy was higher than from mothers who only had a diet. © Advanced Scientific Research. All rights reserved.