Characteristics of immune blood cells in patients with dilated cardiomyopathy: Genesis alcohol and non-alcoholic cardiomyopathy, ischemic type. The comparative role of inflammation TX1 should be -, TX2 - and D classes

The article shows the role of alcohol-induced dilated cardiomyopathy chronic inflammatory process Th-type, and in the pathogenesis of ischemic dilated cardiomyopathy Genesis of the inflammation TX1 should be - and TX2 types. A marked increase in the activity of serum arginase patients, which confirms the opinions expressed in the literature proposals for the use of tests arginase as highly sensitive marker of violations of coronary functions already in the early stages. However, revealed a negative correlation between the activity of arginase and reduced ejection fraction of the left ventricle and atrial fibrillation in patients ICMP show more about the protective role of this enzyme, and do not prove the feasibility of inhibition arginase as a therapeutic target for dilated cardiomyopathy, alcoholic Genesis.

Authors
Panchenko L.F.2 , Moiseev V.S. 1, 3 , Pirozhkov S.V.1, 3 , Terebulina N.N.1, 3 , Naumova T.A.1, 3 , Baronets V.Yu.1, 3 , Goncharov A.S. 1, 3
Journal
Number of issue
5
Language
Russian
Pages
251-259
Status
Published
Volume
35
Year
2014
Organizations
  • 1 Petersburg Scientific Research Institute of General Pathology and Pathophysiology RAMS, Moscow, Russian Federation
  • 2 State Organization National Scientific Center of Narcology, Health Ministry of the Russian Federation, Moscow, Russian Federation
  • 3 Department of Faculty Therapy PFUR, Moscow, Russian Federation
Keywords
Alcohol-induced dilated cardiomyopathy; Arginase; Chronic heart failure
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