Background. When describing the etiological factors of the development of endometrial hyperplastic processes (EHP), the authors emphasize the importance of various viral infections. In this regard, the data on EHP in patients with chronic hepatitis C (CHC) are interesting. Description. The paper gives a clinical case of recurrent EHP in a reproductive-aged patient with CHC. The specific feature of the case is the detection of hepatitis C virus genome in endometrial tissue in moderate viremia. Virological study of endometrial tissue was performed by PCR using the Russian reagent kits: AmpliSens HCV/ HBV/HIV-FL, AmpliSens HCV-monitor-FL, and AmpliSens HIV-monitor-FRT. Antiviral therapy (AVT) normalized the endometrial structure. Conclusion. Virological examination of the endometrium and AVT should be performed in reproductive-aged patients with recurrent EHP in the presence of CHC. © Bionika Media Ltd.