Immunological aspects of allogeneic pregnancy

A review analyses the findings of studies according to which immunoregulation in pregnancy after in vitro fertilization (IVF) with the use of donor oocytes differs from such in natural pregnancy. The number of HLA mismatches influences the number of activated T cells in peripheral blood. In pregnancy after IVF and oocyte donation the mother is exposed to alien cells and antigens, i.e. the situation is comparable with blood transfusion and organ transplantation. Th1 and Th2 cells become hyperactivated. This fact is suggestive that allogeneic foetus induces an additional mechanism contributing to preservation of pregnancy. However, the mechanisms that are involved in this altered immune response have not been fully studied yet.

Authors
Trifonova N.S.1 , Zhukova E.V.2 , Aleksandrov L.S.3 , Simonova A.V. 4 , Ishchenko A.I.3, 5 , Borisova N.I.1 , Nikonov A.P.3
Publisher
Dynasty Publishing House
Number of issue
5
Language
Russian
Pages
59-66
Status
Published
Volume
15
Year
2016
Organizations
  • 1 Clinic of Obstetrics and Gynaecology, University Clinical Hospital No 2, I.M.Sechenov First Moscow State Medical University, 8/2, ul. Trubetskaya, Moscow, 119991, Russian Federation
  • 2 Therapeutic-diagnostic Department No 1, University Clinical Hospital No 2, I.M.Sechenov First Moscow State Medical University, 8/2, ul. Trubetskaya, Moscow, 119991, Russian Federation
  • 3 Research Department of Women's Health, I.M.Sechenov First Moscow State Medical University, 8/2, ul. Trubetskaya, Moscow, 119991, Russian Federation
  • 4 Department of Preventive Medicine, People's Friendship University of Russia, 21/3, ul. Miklukho-Maklaya, Moscow, 117198, Russian Federation
  • 5 Department of Obstetrics and Gynaecology No 1, Faculty of Medicine, I.M.Sechenov First Moscow State Medical University, 8/2, ul. Trubetskaya, Moscow, 119991, Russian Federation
Keywords
Allogeneic foetus; HLA mismatches; Immunoregulation of pregnancy; Oocyte donation
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4185/
Share

Other records