Arterial hypertension and coronary heart diseases development in patients with dyslipoproteinemia against polymorphisms of gp iiia genes and prothrombin gene

The cause of a genetic predisposition to a variety of diseases, including coronary atherosclerosis and coronary heart disease is the presence of defective integrin receptors on the cell surfaces, as well as thrombophilia associated also with prothrombin gene mutations. This paper deals with the study of frequency of alleles of one of the integrins, GPIIIa glycoprotein (β- type III subunit), and prothrombin gene in patients with dyslipidemia. We have established that the presence of allele PLA2 of GPIIIa gene and allele G20210A of prothrombin gene in the genotype of a patient is a genetic risk factor for intensive development of coronary heart disease and hypertension in patients with dyslipidemia, which is associated with a higher incidence of complications and the need for carrying out more comprehensive antihypertensive therapy to stabilize blood pressure.