The study of driving forces and particular changes in the territorial structure (or spatial organization) of the global industry is one of the traditional tasks for specialists in economic geography and economists. Its relevance is confirmed by the significantly accelerated processes dynamics in the context of globalization. The article shows that the structural approach in the study of changes in the spatial organization of the world industry must be combined with systemic and historical approaches. Therefore, the article presents the analysis of changes in the global industry for 50 years based on described selected research methodology. The authors reveal the forces, which have influenced the spatial organization of global industrial production, as well as characterizes structural changes and migration processes in the global industry taking place in the second half of the XX century. It is noted that the point of influence of the global industrial production has shifted to the Asian region. © 2016, ASERS Publishing House. All rights reserved.