Endometrial morphological and immunohistochemical features in females with primary and secondary infertility

Endometrial scrapes and biopsy specimens from 47 females with primary and secondary infertility were studied by histological and immnohistological (estrogen and progesterone receptors, Ki67) methods. Endometrial abnormalities, such as luteal phase defect, hyperplasia, endometrial polyps, and chronic endometritis, were detected in all the patients. There were considerable changes in the expression of estrogen and progesterone receptors and impaired endometrial proliferative processes. There was no clear correlation of immunohistochemical parameters with blood hormone levels in both primary and secondary infertility. The findings may be of significance in choosing the schemes of assisted procreation technologies.