Matrix metalloproteinases 2, 7, and 9 in tumors and sera of patients with breast cancer

Enzyme immunoassay showed that the content of matrix metalloproteinases (MMP) 2 and 7 in tumors was higher than in the adjacent histologically intact tissue in 91 and 76% patients with breast cancer, respectively, while MMP-9 levels in the tumor and intact tissue were virtually the same. Serum concentrations of MMP-2 and MMP-7 did not correlate with their levels in the tumors, were within the normal range, and virtually did not decrease after removal of the primary tumor. Serum levels of MMP-9 in patients were significantly lower than in the control and increased after surgery in 85% patients. No clear-cut relationship between the studied parameters and clinical morphological prognostic factors of breast cancer was detected. © 2011 Springer Science+Business Media, Inc.

Authors
Katunina A.I.1 , Gershtein E.S.1 , Ermilova V.D.1 , Tereshkina I.V.1 , Nazarenko A.Yu. 2 , Tyleuova A.A.1 , Dvorova E.K.1 , Karabekova Z.K.1 , Gritskevich M.V.1 , Berezov T.T. 2
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
359-362
Status
Published
Volume
151
Year
2011
Organizations
  • 1 N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation
  • 2 Peoples' Friendship University of Russia, Moscow, Russian Federation
Keywords
breast cancer; enzyme immunoassay; histology; matrix metalloproteinase
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2530/
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