We assessed prognostic value of clinical-laboratory and instrumental parameters in 100 patients with acute decompensation of chronic heart failure (CHF) in relation to hospital mortality. Independent predictors of lethal outcome in patients with acute decompensation of CHF were low systolic arterial pressure at admission (odds ratio [OR] 1.03, 95% confidence interval [CI] 1.01 to 1.05 per each 1 mm Hg of blood pressure lowering), elevation of urea content (OR 1.29, 95%CI 1.11 to 1.47 per each 1 mmol/L of elevation), potassium (OR 2.09, 95%C11.08 to 4.38 per 1 mmol/L of elevation) and creatinine (OR 1.01, 95%CI 1.01 to 1.03 per 1 mmol/L of elevation), lowering of glomerular filtration rate (OR 1.29, 95%CI 1.18 to 1.41 per 1 ml/min/1,73 m2of lowering), left ventricular dilatation (OR 9.53, 95%CI 1.44 to 38.17; p=0.043), pulmonary hypertension according to echocardiography data (p=0.007), scarry changes according to electrocardiography data (OR 3.00, 95%CI 1.00 to 10.58; p=0.05), lack of therapy with acetylsalicylic acid (OR 6.21, 95%CI 1.62 to 22.73; p=0.009) and β-adrenoblockers (OR 6.99, 95%CI 1.39 to 14.49; p=0,005) at ambulatory stage.