In 114 patients the serotonin level in the blood was studied by means of the fluorimetric method. A group of healthy persons was also observed, in whom the level of the serotonin in the blood in fasting condition was 0.189 γ/ml. The dynamics of the serotonin was studied in relation to the phase of digestion: in the intact stomach with normal passage of food, at 15-20 min after a meal the serotonin level had some tendency to decrease; after gastric resection by the Billroth II method it remained stable, but in the majority of patients it was elevated. After gastric resections with gastroplasty the serotonin level had a tendency to decrease. The figures of the serotonin could be used for functional evaluation of different methods of gastric resection.