Effect of sodium salicylate, acetylsalicylic and 2,3 dioxybenzoic acids and 2,3 diacetoxybenzoic acids on the blood clotting system and heparin elimination

Tests on rabbits showed that on long term enteral administration (at doses of 200 mg/kg, twice daily for 10 days), 2,3 diacetoxybenzoic acid, sodium salicylate and 2,3 diacetobenzoic acid inhibit the coagulation potential of blood. 2,3 Diacetoxybenzoic acid exerted also a hypocoagulational action following a single administration at a dose of 400 mg/kg. All of the test compounds raised the level of endogenous heparin and potentiated the anti coagulation activity of heparin. 2,3 Dioxybenzoic acid reduced slightly the concentration and the anti clotting effect of exogenic heparin.