THE INFLUENCE OF CUTOKINE THERAPY ON ULTRASOUND ASSESSMENT OF UTERINE HEMODYNAMICS IN TREATMENT OF CHRONIC ENDOMETRITIS

Objective: To evaluate the effect of chronic endometritis treatment including cytokine therapy on uterine artery and endometrial blood flows. Materials and methods: The retrospective analysis of 298 women of reproductive age with a verified diagnosis of chronic endometritis was performed. The main group consisted of 140 patients. The patients received standard anti-inflammatory therapy and cytokine therapy (the drug Superlymph). The comparison group included 158 patients who received similar treatment, but without cytokine therapy. Doppler sonography assessment of uterine artery blood flow and calculation of arterial perfusion index (PI), as well as VI, FI and VFI was performed. Results: After therapy in combination with treatment with cytokines, there was redistribution of arteriovenous blood flow and restoration of balanced microcirculation, so that the blood volume of the arterial bed was in compliance with venous blood volume. This was evidenced by a significantly decreased uterine artery and endometrial VI, FI and VFI, and relatively stable arterial PI. Hypervascularization of the uterus and endometrium during the inflammatory process was caused by venous outflow obstruction, but not by increased arterial inflow. Conclusion: The effectiveness of anti-inflammatory therapy for chronic endometritis in combination with treatment with exogenous cytokines improves the hemodynamics of the uterus and endometrium by restoring venous outflow. © A group of authors, 2024.