PROSPECTS FOR USING ULTRASOUND OF VARIOUS INTENSITY FOR THE TREATMENT OF PATIENTS WITH MALIGNANT BRAIN GLIOMAS; [ПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ УЛЬТРАЗВУКА РАЗЛИЧНОЙ ИНТЕНСИВНОСТИ ДЛЯ ЛЕЧЕНИЯ ПАЦИЕНТОВ СО ЗЛОКАЧЕСТВЕННЫМИ ГЛИОМАМИ ГОЛОВНОГО МОЗГА]

Background. Treatment for malignant brain gliomas includes surgery, radiation therapy, and chemotherapy with temozolomide. However, this complex treatment does not prevent tumor relapses and progression, which is caused by the activity oftumor cells anda highmutationalburden. Researchers are experimenting withdifferent intensity offocusedultrasound (FUS)in the treatment of glioblastoma (GBM). FUS has shown encouraging results in clinical studies. The aim ofthe study. This review presents briefinformation on the history ofthe development of the studied method, the results of its application in experiments and clinical trials, as well as the main possible directions for its implementation in neuro-oncology, in particular, for the treatment of glioblastomas, depending on parameters, including frequency, power, pulse duration and duty cycle. Methods. We carried out an analysis and interpretation of existing publications; for the search, we usedthe PubMeddatabase andthe keywords“focusedultrasound, glioma, HIFU, LIFU”, as well as Yandex and Google search engines and the same keywords in Russian. Results. Low-intensity FUScan be usedto temporarily open the blood-brain barrier (BBB), which limits the diffusion of most macromolecules and therapeutic agents into the brain. High-intensity FUS can cause tumor ablation due to a hyperthermic effect, andalso stimulate an immunologicalattackoftumor cells, activate sonosensitizers to exert a cytotoxic effect on tumor tissue, and can increase the sensitivity of tumors to radiation therapy. Histotripsy causes tumor ablation through acoustic cavitation. Conclusion. Focused ultrasound is a promising potential treatment for gliomas. Further study in the form of clinical trials should determine the optimal ultrasound parameters to achieve effective treatment for patients withmalignant brain tumors. © 2024 Scientific Centre for Family Health and Human Reproduction Problems. All rights reserved.