Significance of corticosteroids binding to blood plasma proteins in the mechanism of the rs-10 radioprotector affecting the function of the adrenal cortex; [Importancia de la unión de corticosteroides a proteínas del plasma sanguíneo en el mecanismo del radioprotector RS-10 que afecta la función de la corteza suprarrenal]

The relevance of research on the preventive properties of chemical radioprotectors is currently due to the need to implement a system of radiation safety measures for the population. The study aimed to investigate the significance of corticosteroid binding to plasma proteins in the mechanism of influence of the radioprotector RS-10 on adrenal cortical function in healthy and irradiated animals. Experiments were carried out on 60 male rabbits of the chinchilla breed. In the first series of experiments, the reaction of the adrenal cortex and the processes of binding them to proteins after administration of RS-10 intact animals were studied; in the second series - the same indicators in animals exposed to RS-10 prophylactic administration. Rabbits were irradiated totally with 8 Gy rays. RS-10 (chitosan bitartrate) was administered intravenously at 10.0 mg/kg 15 minutes before irradiation. The control animals were administered an equivalent volume of saline. In the dynamics of radiation sickness in protected RS-10 rabbits, a significantly lower decrease in the binding ability of corticosteroid-binding globulin (CSG) was observed than in control animals. Prophylactic administration of RS-10 before irradiation reduces the free hormone level and, as a result, leads to a decrease in hypercorticism, increasing the reserve capabilities of the binding ability of the CSG at the height of radiation sickness. © 2023 All rights reserved.