The relevance of this research lies in the fact that new trends of decentralization and regionalization are intensifying in today’s world economy. These trends require additional scientific research. The paper aims to analyze the socio-economic processes and international cooperation of countries in the Levant region. The authors found that the Levant region, which includes Turkey, Egypt, Iraq, and Lebanon, sees an increase in economic interaction, the role of which increases for national economies and the region of the Middle East and North Africa. The research shows that there are certain objective prerequisites for developing Levantine cooperation at the country, regional, and global levels. Economic cooperation within the Levant can be seen as one of the contemporary mechanisms for ensuring more sustainable development of the participating countries and the region as a whole. The research novelty lies in identifying the features of international economic cooperation in the Levant, its directions, and possible effects. The authors found that the Levant countries will intensify their trade and economic cooperation. It covers not only mutual trade but also the implementation of joint projects of long-term and strategic importance for these countries. The information for this research is based on UNCTAD statistics and previous studies on the subject. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.