Due to the rapid development of the space industry, running on the board of the space station should also be addressed. Space is a hostile environment for humans. While staying in microgravity conditions, the work of all body systems deconditions, particularly the musculoskeletal system. At the moment, running is the main way to combat the negative impact of weightlessness on the human body. Therefore, a special training program has been established. Currently, crewmembers are prescribed to train 2.5 h a day 6-7 days a week with one strengthening session and one aerobic session a day. While running on treadmill in space, cosmonauts must strap themselves with bungee cords to replicate the moment of landing and to keep from floating off. © The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2022. All rights reserved.