Chronic sterile inflammation in the pathogenesis of benign myometrial diseases

This article presents an analysis of current literary sources on the role of chronic sterile inflammation in the development of proliferative diseases of the myometrium (adenomyosis, uterine fibroids). DAMPs (damage-associated molecular patterns) are considered as a significant marker of inflammation severity in these diseases. The pathogenesis of both uterine fibroids and adenomyosis is based on similar mechanisms related to chronic sterile inflammation in response to abnormal cell division. Neoangiogenesis, neoneurogenesis and fibrosis are likely to be the result of inflammation and contribute to the progression of pathological process, as well as determine its clinical manifestations (pain, heavy menstrual bleeding, infertility, miscarriage, etc.). The development of a particular pattern of pathological processes (uterine fibroids or adenomyosis) is determined by genetic and epigenetic mechanisms. Further studies of proliferative diseases of the myometrium should examine in more detail the systemic immune profile and cellular composition of the myometrium, uterine fibroids and adenomyosis to better understand the role of chronic inflammatory processes in the pathogenesis of myometrial proliferative diseases. © 2024, Dynasty Publishing House. All rights reserved.