Smoking is associated with altered serum and hair essential metal and metalloid levels in women

The objective of the study was to evaluate the association between smoking and essential metal (Co, Cr, Cu, Fe, Mn, V, Zn) and metalloid (Se) levels in hair and serum of adult women using inductively coupled plasma-mass spectrometry (ICP-MS). In this cross-sectional study, a total of 344 women 20–70 years old including 199 smokers and 145 non-smoking women were enrolled. Serum Cu, Fe, and Zn levels in smoking women were found to be 6%, 8%, and 3% lower of levels in non-smokers, respectively. In contrast, circulating Mn, V, and especially Cr concentrations in smoking women exceeded the respective values in non-smoking women by 5%, 14%, and 54%. Hair Fe and Se levels in smoking women were 17% and 23% lower as compared to non-smoking controls, respectively. In multiple regression models, smoking severity was inversely associated with serum and hair Se concentrations, whereas the relationship to serum and hair Cr was positive. In addition, serum Zn and hair Fe levels were found to be inversely associated with the number of cigarettes per day. These findings hypothesize that health hazards of smoking may be at least in part be mediated by alteration in essential metal and metalloid metabolism. © 2022 Elsevier Ltd

Authors
Skalny A.V. , Serebryansky E.P. , Korobeinikova T.V. , Tsatsakis A. , Vardavas C. , Paoliello M.M.B. , Sotnikova T.I. , Aschner M. , Tinkov A.A.
Publisher
Elsevier Ltd
Language
English
Status
Published
Number
113249
Volume
167
Year
2022
Organizations
  • 1 IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119435, Russian Federation
  • 2 Peoples’ Friendship University of Russia (RUDN University), 117198, Moscow, Russian Federation
  • 3 Micronutrients Ltd, Moscow, 105082, Russian Federation
  • 4 Laboratory of Toxicology, Medical School, University of Crete, Voutes, Crete, Heraklion, 700 13, Greece
  • 5 Center for Global Tobacco Control, Harvard School of Public Health, Boston, 02115, United States
  • 6 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, 10461, NY, United States
  • 7 City Clinical Hospital n. a. S.P. Botkin of the Moscow City Health Department, 125284, Moscow, Russian Federation
  • 8 Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl, 150003, Russian Federation
Keywords
Chromium; Cigarettes; Selenium; Tobacco; Zinc
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