7-Methylguanine Inhibits Colon Cancer Growthin Vivo

7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.

Authors
Kirsanov K.I.1, 2 , Fetisov T.I.1 , Antoshina E.E.1 , Gor’kova T.G.1 , Trukhanova L.S.1 , Shram S.I.3 , Nagaev I.Yu.3 , Zolotarev Yu.A.3 , Abo Qoura L.1, 2 , Pokrovsky V.S. 1, 2 , Yakubovskaya M.G.1 , Švedas V.K.4, 5 , Nilov D.K.4
Publisher
Общество с ограниченной ответственностью «АКТА НАТУРЭ»
Number of issue
2
Language
English
Pages
50-52
Status
Published
Department
Кафедра биохимии имени академика Т.Т. Березова
Number
16
Volume
16
Year
2024
Organizations
  • 1 Blokhin National Medical Research Center of Oncology, Institute of Carcinogenesis
  • 2 RUDN University, Medical Institute
  • 3 National Research Centre “Kurchatov Institute
  • 4 Lomonosov Moscow State University, Belozersky Institute of Physicochemical Biolog
  • 5 Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatic
Keywords
7-methylguanine; inhibitor; poly(ADP-ribose) polymerase 1; tRNA-guanine transglycosylase; co-lon cancer; BALB/c mice
Date of creation
05.11.2024
Date of change
05.11.2024
Short link
https://repository.rudn.ru/en/records/article/record/157703/
Share

Other records

Brezgin Sergey, Frolova Anastasia, Bayurova Ekaterina, Slatinskaya Olga, Ponomareva Natalia, Parshina Evgeniia, Bochkova Zhanna, Kachanov Artyom, Tikhonov Andrey, Kostyusheva Anastasiya, Karandashov Ivan, Demina Polina, Latyshev Oleg, Eliseeva Olesja, Belikova Maria, Pokrovsky Vadim S., Gegechkory Vladimir, Khaydukov Evgeny, Silachev Denis, Zamyatnin Jr Andrey A., Maksimov Georgy, Lukashev Alexander, Gordeychuk Ilya, Chulanov Vladimir, Kostyushev Dmitry
Analytical Chemistry. American Chemical Society. Vol. 96. 2024. P. 17432-17443