The aim of the study is to study the significance and advantage of personalized modeling and surgical navigation in patients with mature teratomas during laparoscopic cystectomy. Materials and methods. A comprehensive clinical and laboratory examination and treatment of 100 patients with mature ovarian teratomas was carried out. The main group consisted of 50 patients with mature teratomas who underwent preoperative modeling and surgical navigation during cyst removal. The comparison group included 50 patients with mature teratomas who underwent surgical treatment according to the standard technique. Results. Modeling and surgical navigation in the preoperative period make it possible to conduct focused coagulation of vascular zones, which allows minimizing blood loss and trauma to healthy ovarian tissue during cystectomy in patients with mature teratoma. An analysis of the traumatism of surgical intervention after laparoscopic cystectomy (removal of a mature teratoma) showed a significant reduction in traumatism when using modeling and surgical navigation (the main group - a low degree of traumatism in 86% of patients, medium - in 14%, in the comparison group - in 8% and 92%, respectively). ), which allows you to rehabilitate and restore the quality of life in the shortest possible time.