THE ZINC PHTHALOCYANINE AND AN ANTI-CANCER DRUG ON THE BASIS IT

The technology of preparation of the drug - thermosensor in the treatment of cancer of the skin and mucous one of the variants of the method of pulsed laser hyperthermia - pulsed laser ablation of nanoparticles (PLAN). The drug is a stable nanodispersion of zinc phthalocyanine. Nanoparticles of the drug with blood flow enter the tumor, after which the tumor irradiated with a pulsed laser, nanoparticles that absorb light at the laser radiation length, explode, thereby destroying the tumor tissue and its capillary blood system, which leads to the oppression of the tumor, its degradation and death. The technology consists in two-stage dispersion of large-crystalline zinc phthalocyanine. The first stage is grinding into heavy-type mixers using salts as grinding crystals; the second stage is dispersing by ultrasound in the presence of surfactants. The drug successfully passed preclinical tests on animals.