The tasks of digitalization in general, the development of training programs for distance learning in medical and natural sciences are becoming increasingly relevant in recent years. In this paper we present approaches to the development of online bioinformatics training courses used in several Moscow universities. The epidemic situation that has continued over the past two years has accelerated the adoption of distance learning measures and revealed a number of new organizational problems. Understanding and reliable perception of educational materials by students when combining different forms of learning (face-to-face, distance, mixed forms) require development of new approaches to the testing, knowledge checking, independent fulfillment of educational tasks using online programs. The experience of organizing a training course on the basics of bioinformatics and online databases management is discussed