In this work the terms prapatti and tawakkul are considered as similar ones in sense and value in the Vaiṣṇava and Sufi religious and philosophical traditions. Both terms mean the condition of self-surrender to God which lead the devotees to the spiritual realization in the scope of the particular tradition. The doctrine of prapatti take a special place in Vaiṣṇavism. It origins arise at least from Pāñcarātra saṃhitās and religious poetry of the Āḻvārs (aprox. 6-10th cent.). It is regarded as the alternative path to achieve the salvation of soul (mokṣa) which is the main goal of Indian philosophy along with bhakti, jñāna and karma yoga. The same concept can be found in Sufism. Tawakkul is one of the main stages (maqām) on the Sufi Mystical Path. Same as prapatti it expresses the special condition of a full self-surrender and trust in the will of God. It is the fundamental principle of Sufism. This work is dedicated to the comparative study of the mentioned terms and it is aimed to highlight the differences and similarities in their understanding and interpretation inside the traditions. The requirements and prescriptions to the practices of prapatti and tawakkul are also reviewed.