Мехатронное устройство для химиотерапии

Исследован термодинамический профиль опухоли для математического моделирования с последующей разработкой алгоритмического, программного и информационного обеспечения инфузотелемата. Представлены биомедицинские принципы конструирования дозаторной роботизированной системы для пролонгированного введения цитостатиков. Создан действующий телемедицинский прототип роботизированной дозаторной системы для введения противоопухолевых лекарственных препаратов, работающей по принципам обратной связи, основанной на анализе изменений температур в опухоли и учитывающей индивидуальные особенности распределения глубинных температур в организме пациента.

Mechatronic system for infusion of cytostatics

Anticancer chemotherapy as a dynamically evolving scientific and practical direction in Oncology refers to the main methods of treatment of malignant tumors. This direction are connected with substantial success in increasing life expectancy of cancer patients. Progress in chemotherapy is largely due to the numerous studies on the development and introduction into clinical practice of new types of anticancer drugs. Equally important promising area of development of chemotherapy is the study of individual sensitivity of tumors to some cytotoxic drugs. One of the main features of malignant tumors is their polyclonality. This means that in the cell population of the tumor, there are many genetically different from each other subpopulations. This genetic heterogeneity may occur, including, and unequal cell division rate, i.e. the differential rate of mitosis. Thus, at any given point in time in the tumor can present cells in the resting phase, and cells in different phases of mitotic cycle. The ratio between these two populations of cells is not stable and depends on many internal and external factors. On the other hand, it is known that only cells located in.the different phases of mitosis are, in varying degrees, sensitive to the action of cytostatics. The introduction of anticancer drugs during the periods when most of the potentially proliferating cells is in mitosis may be an additional factor increasing therapeutic effects of chemotherapy. To achieve these goals is justified the use of modes of a continuous infusion with the help of specialized devices dosing. Define time periods for the development of specific tumors in which a significant part of the cell population is in the mitotic phase of the cycle is difficult to end an unresolved challenge. One of the possible approaches to the definition of these periods is the dynamic thermometry of the tumor. A comprehensive study of the thermodynamic characteristics of the tumors serve as a scientific basis for the creation of fundamentally new types of automatic dispensers of medicines, operating on the principles of biological feedback based on the mathematical analysis of temperature changes in the tumor. Implemented variety of transmission technologies developed structures of information and microprocessor systems for measurement of temperature. Designed technical design and developed software for the functioning biotelemetric system. At the organization of the data transmission channel implemented standard features for this class of telemedicine networks. Created original computer system allows the combined analysis of local thermometry, as well as medical images obtained by computed x-ray tomography, positron emission tomography, magnetic resonance imaging and ultrasound. The authors conclude that this robotic dispensing system is necessary for anticancer therapy.