PEOPLE. SCIENCE. INNOVATIONS IN THE NEW MILLENNIUM: Proceedings of the International Youth Scientific Conference. Moscow, November 23–25, 2015. PART 1.
РУДН.
2015.
P. 24-27
OBTAINING SINGLE DOMAIN NANOBODIES SPECIFIC FOR HUMAN INTERFERON-β AND THEIR USE IN AFFINITY PURIFICATION
Blood of camelids contains both conventional heterotetrameric antibodies and unique functional heavy-chain antibodies. Single-domain antigen-binding fragments of these heavychain antibodies, known as VHH or mini-antibodies (nanobodies) began to be used in basic research. In this review attention is paid to obtaining nanobodies specific for human interferon-β in order to obtain a preparation with high biological activity for application in mass production.
Authors
Antropova N.S.
1
,
Rogozhin V.N.2
Conference proceedings
Publisher
РУДН
Language
English
Pages
3-7
Status
Published
Year
2015
Organizations
- 1 Peoples' Friendship University of Russia
- 2 K.I.Scriabin State Academy of Veterinary Medicine and Biotechnology
Keywords
affinity purification; antibody; single domain; nanobodies; alpaca; recombinant bacteriophage; e.coli; interferon-β
Date of creation
09.07.2024
Date of change
09.07.2024
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PEOPLE. SCIENCE. INNOVATIONS IN THE NEW MILLENNIUM: Proceedings of the International Youth Scientific Conference. Moscow, November 23–25, 2015. PART 1.
РУДН.
2015.
P. 35-37