Platelets and their fibrinogen receptors may be central to haematogenous cancer spread, in addition to various adhesive proteins on both platelets and tumor cells on themselves. The glycoprotein alpha(IIb)beta3a (GPIIb/IIIa) is the main fibrinogen receptor on platelets. The PLA polymorphism of the beta3 subunit modulates the function of alpha(IIb)beta3a integrin. We examined whether PLA polymorphism of the beta3 subunit modulates the cancer risk and progression of bladder carcinoma Using participants (n = 80) from the Moscow population, we assessed the risk of bladder cancer (BC) in individuals with the PLA polymorphism (heterozygote and homozygote) relative to those without the polymorphism (non-carriers). We conclude that the PLA polymorphism does not modify the cancer risk but it may influence the metastasis spread and the malignant potential of bladder and prostate cancer. The tumor progression for the patients with PLA2 in genotype has a greater rate of local invasion and metastases.