The study is directed to one of actual urologic problems - to improve diagnostic of malignant prostatic neoplasms. Cells have been obtained during biopsy in patients with prostatic diseases (such as chronic prostatitis (CP), benign prostatic hyperplasia (BPH), prostatic intraepithelial neoplasia of high degree (PIN 2 - 3) and prostatic cancer (PC)), and study of level expression of mRNA of vessels endothelial growth factors and it`s receptors with the cells was performed. It was performed analysis of correlation of levels of the studied factors`s mRNA expression to constitutive -actine gene`s mRNA expresion (VEGF/- actine, FLT-1/- actine, KDR/- actine, FLT-1+KDR/- actine и FLT-1+KDR+VEGF/- actine) and it was also performed analyses of correlation of levels of the studied factors`s mRNA expression to each other (VEGF/FLT-1, VEGF/KDR, FLT-1/KDR и FLT-1+KDR/VEGF). It was demonstrated that detection of different correlations of VEGF, KDR и FLT-1 expression levels was criteria of different way to diagnose of above-mentioned prostatic diseases.