Application of Mixing Indices in Modeling Processes in Pharmaceutical Production

Use of the discrete element method made it possible to make progress in modeling such a complex process as mixing. However, choosing a mixing index to evaluate the mixing efficiency of various excipients and pharmaceutical substances is a non-trivial task that makes the systematization and analysis of indices used for modeling critical. Mixing indices used in modern research on modeling the mixing process by the discrete element method starting from the Lacey index and ending with new methods applicable under fluidization conditions are discussed and analyzed.

Authors
Markeev V.B.1 , Blynskaya E.V. 1, 2 , Tishkov S.V. 1 , Alekseev K.V. 1 , Alekseev V.K.1
Number of issue
3
Language
English
Pages
430-440
Status
Published
Volume
57
Year
2023
Organizations
  • 1 Research Zakusov Institute of Pharmacology
  • 2 Peoples’ Friendship University of Russia
Keywords
mixing; mathematical modeling; discrete element method; mixing indices; Lacey index; convection; diffusion; pharmacy; Pharmacology/toxicology; organic chemistry
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