The development of carbon-based nanocomposites as potential materials for biomedical implants has gained significant attention in recent years. Graphene is one of the most promising nanomaterials to be utilized in biomedical field because of its mechanical, biological, and electric properties. Graphene and its derivatives also have shown promising tribological properties, such as improved wear resistance and reduced friction, which are critical for the long-term success of implants. In addition, carbon-based nanocomposites have demonstrated good biocompatibility, making them a potentially attractive option for use in biomedical applications. However, further research is needed to optimize these materials for specific implant types and applications, and to fully understand their tribological and biocompatibility properties in vivo.