5-Amino-1,2,4-triazole-3-carboxamide homologues and their biological potential

New homologues of 5-amino-1,2,4-triazole-3-carboxamide, viz., 5-(w-aminoalkyl)-1,2,4-triazole-3-carboxamides have been synthesized. The intermediate acyloxalamidrazones undergo thermal cyclization to 1,2,4-triazoles with the better yield in the absence of catalyst while in the presence of 10 mol% TsOH the main product is the corresponding 1,3,4-oxadiazole derivative. The obtained compounds have demonstrated various biological properties comparable to those of the nucleoside drug ribavirin. © 2025 Mendeleev Communications.

Авторы
Oleynik Evgeniya S. 1 , Shmarina Anna A. 1 , Mitina Ekaterina R. 1 , Mikhina Ekaterina A. 1 , Semenov Ilya A. 1 , Savina Ekaterina D. 1, 2 , Grebenkina Lyubov E. 1 , Zhidkova E.M. 2 , Lesovaya Ekaterina A. 2, 3, 4 , Vetrova Elizaveta N. 5 , Sineva Olga Nikolaevna 6 , Matveev Andrey V. 1
Журнал
Mendeleev Communications
Издательство
Royal Society of Chemistry
Номер выпуска
5
Язык
Английский
Страницы
606-608
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.71267/MENCOM.7753
Том
35
Год
2025
Организации
  • 1 MIREA - Russian Technological University (RTU MIREA), Moscow, Moscow Oblast, Russian Federation
  • 2 Blokhin National Medical Research Center of Oncology, Ministry of Health, Moscow, Russian Federation
  • 3 RUDN University, Moscow, Moscow Oblast, Russian Federation
  • 4 Ryazan State Medical University, Ryazan, Ryazan Oblast, Russian Federation
  • 5 N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russian Federation
  • 6 Gause Institute of New Antibiotics RAMS, Moscow, Moscow Oblast, Russian Federation
Ключевые слова
1,2,4-triazole-3-carboxylic acid derivatives; 2,4-triazole-3-carboxamides; 5-(w-aminoalkyl)-1; acute lymphoblastic leukemia; acyloxalamidrazones; antimicrobial properties; antiviral agents; chronic myeloid leukemia
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