ГИАЛУРОНОВАЯ КИСЛОТА В КОРРЕКЦИИ ГЕНИТОУРИНАРНОГО МЕНОПАУЗАЛЬНОГО СИНДРОМА У ЖЕНЩИН ПОСЛЕ ПРОТИВООПУХОЛЕВОГО ЛЕЧЕНИЯ

HYALURONIC ACID IN THE CORRECTION OF GENITOURINARY SYNDROME OF MENOPAUSE IN WOMEN AFTER ANTICANCER TREATMENT

Objective: To study the effectiveness of hyaluronic acid in the correction of genitourinary syndrome of menopause in cancer patients after antitumor treatment. Materials and methods: The literature search was conducted in the electronic databases, namely PubMed, Scopus, Web of Science, Cochrane Library, ScienceDirect, Embase, PsycINFO using the keywords in Russian and English. The articles were published between 1987 and 2024. Results: The symptoms of genitourinary syndrome of menopause have a long-term negative impact on the quality of life of women who underwent antitumor treatment for malignant neoplasms. In cases of hormone-dependent forms of the disease, and when patients refuse to receive menopausal hormone therapy, alternative treatment methods become necessary. Currently, there is no single standard for non-hormonal correction of genitourinary syndrome of menopause in this population. The use of hyaluronic acid in both non-injectable and injectable forms for cancer patients is an effective method for addressing problems associated with vulvovaginal atrophy. The safety of volume-forming substances based on hyaluronic acid has also been demonstrated in the absence of disease progression. Conclusion: The analysis of the literature showed the potential for further research into the efficacy and safety of using hyaluronic acid including long-term follow-up to correct vulvovaginal changes in cancer patients after antitumor treatment. This research could help determine whether it should be included in the standard restorative treatment for these patients. Such an approach could improve the quality of life for this patient group and address a number of psychological and socio-economic issues. © A group of authors, 2025.