Crystal structure and Hirshfeld surface analysis of (3aRS,4RS,10SR,10aSR)-2-(3,5-dimethylphenyl)-4-hydroxy-10-methyl-1-oxo-2,3,3a,4,10,10ahexahydro-1H-[1]benzofuro[2,3-f]isoindole-10-carboxylic acid dimethylformamide monosolvate

The molecular conformation of the title compound, C24H23NO5·C3H7NO, is consolidated by intramolecular C—H· · ·O O—H· · ·O hydrogen bonds, forming an S(6) ring motif. In the crystal, the molecules are connected by C—H· · ·O hydrogen bonds, forming layers parallel to the (101) plane. Furthermore, the molecules form layers parallel to the (102) plane by C—H· · ·π interactions. Important intermolecular interactions highlighted by Hirshfeld surface analysis are H· · ·H (54.7%), O· · ·H/H· · ·O (23.0%), and C· · ·H/H· · ·C (19.9%) contacts. © 2025 International Union of Crystallography. All rights reserved.