Objective. To assess the effectiveness of the proposed rehabilitation program for persons with alcohol dependence (AD) occurred in the middle and elderly age and complicated by secondary organic mental disorders (SOMD) in elderly age. Material and methods. The study included male patients aged 67.5±7.2 years, divided into two groups depending on the age of onset of AD: Group 1 included 21 subjects (36.2%) with dependence onset at the age of 51.6±1.2 years, and SOMD symptoms at 61.8±2.1 years; Group 2 included 37 subjects (63.8%) with dependence onset at the age of 64.5±2.5 years and SOMD at 71.3±2.8 years. The following methods were used: questionnaire — social interview; clinical (medical history, follow-up); assessment of mental status using various scales (quantified scale for assessing the severity of psychopathological disorders, clinical scale for assessing pathological alcohol craving, anosognosia scale, “Questionnaire for Assessing the Quality of Remission in Remote and Hard-to-Reach Regions” during the remission); prospective observation; statistical methods (parametric, non-parametric). Results. Rehabilitation and preventive care in both groups resulted in a significant (p<0.05) improvement of psychopathological disorders. After 12 months, patients in Groups 1 and 2 showed an increase in the level of critical attitude toward the disease (p<0.05) relative to the outcome and 6 months of remission. The critical attitude score was 32.0±1.0 and 29.15±1.75 points, respectively. After 6 months, the assessment of self-reported of quality of life showed remission of average quality (65.38±2.16 points in Group 1 and 2 73.25±3.86 points in group), and after 12 months, a satisfactory quality of life and satisfactory implementation of their plans, good family relations (70.22±1.18 points in Group 1 and 80.17±3.69 points in Group 1). Conclusion. The proposed step-by-step differentiated rehabilitation and preventive care program has helped many patients of Groups 1 and 2 achieve remission of medium and high quality, respectively, with a decrease in pathological alcohol craving to a non-significant grade that occurs contextually. © 2025, Media Sphera Publishing Group. All rights reserved.