In Russia, soybean Glycine max cultivation covers over 3 million hectares, but the low average yield leaves the potential of this crop in Russia still unattainable. Soybean diseases are among the main obstacles to increasing soybean yields. Chemical control remains an important tool for managing bacterial diseases, as most soybean cultivars are susceptible, but the list of recommended pesticides is very short. We screened 17 commercial pesticides with reported antibacterial activity as potential agents to combat bacterial blight and bacterial tan spot/wilt of soybeans. Several methods were used to carry out the assay: in vitro screening and determination of the minimal bactericidal concentrations, analysis of phytotoxicity, and testing biological efficiency on seeds and leaves after artificial inoculation with pathogens. The results presented here show that all tested pesticides possessed a significant antibacterial effect in vitro. Still, some plant protection agents (Kocide 2000, Serebromedin, Kasumin, and Phytoplasmin) had a phytotoxic impact on germinating seeds and on green plants, at least in the early vegetation stage, when applied at the rates recommended by the manufacturers. The results showed that for seed treatment to control bacterial blight Pseudomonas savastanoi pv. glycinea, pesticide Thiram (TMTD) was the most effective (39% efficacy compared to control), while for the disease on vegetating plants, variants treated with Physan 20 and Daimondaisen showed the highest efficacy (54.5% and 45.5%, respectively). For bacterial tan spot/wilt, Curtobacterium flaccumfaciens pv. flaccumfaciens on germinating seeds, the highest efficacy was shown with the Ridomil Gold treatment (66.2% efficiency by AUPDC), and on vegetating plants, with Diamondasen (reduction of disease severity by 64.4%). Our results allow us to recommend these pesticides for controlling two primary bacterial diseases of soybean. © 2025, Tarbiat Modares University. All rights reserved.