International Journal on Minority and Group Rights. Том 10. 2003. С. 203-220
CuCN-Catalyzed Synthesis of 11-R1-5,6-Dihydro-1H-pyrrolo[2,1-b][3]benzazepines from 1-R1-1-Ethynyl-2-vinyl-1,2,3,4-tetrahydroisoquinolines
A two-step protocol, involving Michael addition with following C-1 alkynylation of readily available 1-R1-substituted tetrahydroisoquinolines with methyl propiolate and CuCN-mediated intramolecular cyclization, was employed to obtain 11-R1-substituted 1H-pyrrolo[2,1-b][3]benzazepines. A method for converting 1H-pyrrolo[2,1-b][3]benzazepines into their structural isomers has been developed. © 2025 American Chemical Society
Авторы
Journal
Номер выпуска
35
Язык
English
Страницы
12490-12495
Статус
Published
Ссылка
Том
90
Год
2025
Организации
- 1 Department of Organic Chemistry, RUDN University, Moscow, Moscow Oblast, Russian Federation
Ключевые слова
Addition reactions; Copper compounds; Plants (botany); Synthesis (chemical); Alkynylations; Catalyzed synthesis; Ethynyl; Intramolecular cyclizations; Michael additions; Structural isomers; Tetrahydroisoquinolines; Two-step protocol; Isomers; 5,6 dihydro 1 h pyrrolo[2,1 b ][3]benzazepine derivative; benzazepine derivative; copper; cyanide; tetrahydroisoquinoline derivative; unclassified drug; alkynylation; Article; carbon nuclear magnetic resonance; catalysis; chemical modification; controlled study; cyclization; electrospray; environmental temperature; Fourier transform infrared spectroscopy; heteronuclear multiple bond correlation; heteronuclear multiple quantum coherence; isomer; Michael addition; microwave irradiation; nuclear Overhauser effect; nucleophilicity; proton nuclear magnetic resonance; reaction analysis; reaction time; rearrangement reaction; structure analysis; substitution reaction; synthesis; thin layer chromatography
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