Purpose. To determine common (including systemic) concomitant diseases in patients with chronic blepharitis. Material and methods. The study included 121 patients aged 18 to 82 years (70 women and 51 men). A standard ophthalmological examination was performed. Concomitant pathology was identified based on examinations by a therapist, cardiologist, gastroenterologist and other specialists. Results. Of the general (including systemic) concomitant diseases in patients with chronic blepharitis, the most common connection is with cardiovascular diseases and coronary heart disease (57.2%), gastroduodenitis or peptic ulcer of the stomach or duodenum (27.6%), as well as osteoporosis (12.3%). © 2024, Ophthalmology Publishing house. All rights reserved.